Cancer Vaccines

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Description

Dendritic cells (DC) are key players in several types of cancer vaccines. Large numbers of DC can easily be
generated in closed systems from the monocyte fraction of the peripheral blood. They are the professional
antigen-presenting cells, and electroporation of mRNA-encoding tumor antigens is a very effi cient and a
relatively simple way to load the DC with antigen. The co-electroporation of a tumor antigen of choice
and the combination of 3 costimulatory molecules, including CD70, caTLR4, and CD40L (TriMix-DC),
leads to fully potent antigen-presenting DC able to generate a broad immune response.